Evidence One of the first signs of Alzheimer’s disease (AD) is loss of smell. He led a group of scientists from the University of Colorado Anschutz in Aurora, in the United States, to investigate the relationship between viral infection and inflammation, and dysregulation of myelination of the olfactory system, which can lead to disruption of hippocampus function.

According to Andrew Bubak, a professor in the Anschutz Department of Neurology, first author of the study, “The entire olfactory pathway goes to the hippocampus. If you reduce the signal along this pathway, you get less signal to the hippocampus. If you don’t use it, you lose.”

In other words, common viruses can inflame and disrupt the connections between our olfactory system and the crucial part of the brain associated with memory and learning. a gap in the human brain that could theoretically accelerate the onset of AD, according to research. If the hypothesis is proven, this opens a field for new treatments that can detect degenerative disease early.

How did researchers discover the relationship between the nose and hippocampus?

Published on Tuesday (13) in the scientific journal Neurobiology of AgingResearch has focused on the olfactory pathway, olfactory bulb, and hippocampus, the brain region that is central to human memory and learning. For this, messenger RNA from the brain tissue of six people with familial Alzheimer’s disease (FAD) in Colombia was examined.

By comparing these samples with tissue from a control group without dementia, the researchers detected additional signs of viral infection in the olfactory bulbs of the FAD group. Inflammation of the olfactory pathway that carries information to the hippocampuswith traces of altered myelination in the olfactory tract.

The findings support the hypothesis that a combination of viral infections, inflammation, and demyelination of the olfactory system may impair hippocampal function. and accelerates Alzheimer’s.

ARTICLE Neurobiology of Aging – DOI: 10.1016/j.neurobiolaging.2022.12.004.

Source: Tec Mundo

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I am Bret Jackson, a professional journalist and author for Gadget Onus, where I specialize in writing about the gaming industry. With over 6 years of experience in my field, I have built up an extensive portfolio that ranges from reviews to interviews with top figures within the industry. My work has been featured on various news sites, providing readers with insightful analysis regarding the current state of gaming culture.

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