Many people have fear of needles. Even for those who don’t have it, the injection can be very uncomfortable. For this reason, the invention of the University of Texas presented today in Annual Congress of the American Chemical Society looks especially promising. This injection which injects its contents through the skin, simply Air sip.
People receiving the injection will only perceive light cranemuch less painful than a needle. This would be useful for those who are afraid of needles, but this is not its only advantage. You can also manage powder contentWhat does not need refrigerationso it will be much easier to transport it, especially to those countries where the existing infrastructure makes it difficult to store it.
At the moment this interesting air injection is at a very early stage. However, the first results were very promising and they hope they will be useful. both veterinary and agricultural and why not?, also in medicine with people
An injection of air that came out of boredom
During self-isolation mode due to the COVID-19 pandemicdoctor Jeremiah Gassensmith bought all components cheap jet injection system. I wanted to kill time riding it; but in fact it was only when he returned to work that he found its final use. Back at the University of Texas, he told one of his students: Yalini VidesundaraLet him try to see what he can do with it.
She thought about it until she remembered some investigations of the 60s in which they used compressed gas enter narrow jet of liquid. In fact, administering vaccines in this way has become very popular among army. The possible problem of fear of needles was solved, and these drugs could be administered very quickly. But there was a big drawback, as sometimes the liquid came out shot back. This made it possible for other diseases to spread, so the method of administration changed.
For this reason, Videsundara thought that the solution might be to change the contents of the injection to something solid. To do this, of course, you will have to make changes to the administration mechanism. And that’s how it came to his mind to use something known as metal-organic frameworks (MOF).
Much more than a solution to the fear of needles
MOFs are composed of porous crystalline structures that act as cells molecular to encapsulate a wide range of materials including nucleic acids such as DNA and proteins.
Videsundara connected the air injector given to him by the professor with the MOF and obtained a mechanism capable of injecting powdered substances to the cells, just a jet of air through the skin. The selected MOF has been named zeolite frame-imidazolate-8, or ZIF-8. As a rule, such devices are manufactured with gold and tungsten. However, there are two main problems. For one it is quite expensive. On the other hand, gold can accelerate the degradation of biological materials after penetration into the skin. These two shortcomings are eliminated with the help of ZIF-8.
One day cell, these scientists focused on gas injectors. ZIF-8 is sensitive to acidic environment. In addition, carbon dioxide reacts with water in cells to form carbonic acid. Therefore, if CO₂ is injected as an injection gas, its contents are released quickly, since carbonic acid breaks V cell in which the drug is located. On the other hand, if ordinary air is used, it takes 4 or 5 days. This is very useful as you can play around with the gas depending on whether you need it or not. quick release or something longer.
Wide range of possibilities for this injection
So far, these scientists have used their injection to administer a gene in onion cells; and a protein in mouse cells.
They also began to study management chemotherapy in melanoma cells. And so far all the results are positive.
For this reason, although they are still in their initial stages, they hope that their injection could be useful in plant genetic engineering and in veterinary medicine. But it could also help deliver chemotherapy and drugs like vaccines to people. This would be very useful for those who are afraid of needles, and much more convenient for the rest. After all, no one likes to get a flat tire.
Source: Hiper Textual
