The study, published in the journal Nature Communications, reveals the role of Gas5 in regulating the transport and clustering of RNA in the long processes of neurons, affecting the excitability of neurons in real time. Gas5 appears to be a critical memory player in fear extinction, providing new insights into the complex world of RNA involvement in the brain.
This finding builds on previous findings establishing a link between learning-related RNAs and synaptic function. The team identifies specific RNAs, including Malat1, decorated with the chemical tag N6-methyladenosine (m6A), that influence synaptic plasticity and memory formation.
Chief writer Dr. Sachitrani Madugalle highlights the potential of RNA therapy in treating conditions such as post-traumatic stress disorder (PTSD).
Source: Ferra
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