Unlike existing CD19 CAR T therapies, AT101 uses a unique epitope located closer to the cell membrane and has demonstrated superior efficacy in preclinical studies. In a study of 12 patients with relapsed or refractory B-cell non-Hodgkin lymphoma, all six patients treated with higher doses of AT101 achieved a complete response without recurrence at 6.5 months.
Remarkably, the therapy showed manageable side effects and has paved the way for potentially innovative advances in cancer treatment. Chief investigator Dr. Marco Ruella expressed his optimism about the findings and underlined the promising potential of the study as it moves into the second phase.
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Source: Ferra
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