The study was published in the journal Opto-Electronic Advances.
The nanoparticles consist of Prussian blue, which releases NO when exposed to laser, and the photosensitizer Ce6 placed on their surface. This combination provides simultaneous photodynamic and photothermal tumor therapy.
The released NO interacts with ROS to form RNS, which significantly increases the antitumor effect and stimulates the body’s immune response.
Laboratory studies have shown the high effectiveness of this method compared to traditional treatment. Treatment with PBNO-Ce6 nanoparticles caused a 2.7-fold increase in the number of cytotoxic T lymphocytes (which kill tumor cells) and a 62% decrease in regulatory T cells (which suppress the immune response).
Scientists believe this technique could be an important part of complex cancer treatment in combination with immunotherapy or chemotherapy.
Source: Ferra
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