According to scientists, this gene controls appetite and energy expenditure. Obesity occurs due to an imbalance: we either eat too much or spend too little energy. Experiments in mice have shown that stimulating neurons expressing SH2B1 suppresses appetite, and shutting them down leads to obesity.
Scientists also found that the SH2B1 gene affects the BDNF/TrkB signaling pathway, which is important for brain development and health. Disruption of this pathway is associated with obesity and metabolic diseases. Scientists see great potential in increasing the activity of SH2B1 in treating obesity and related diseases.
It is stated that, unlike some modern drugs for weight loss, no side effects have yet been discovered due to the increase in SH2B1 activity.
Source: Ferra
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