The study, published in Nature Communications, found that a group of proteins involved in “SUMOylation,” a process in which the small protein SUMO tags other proteins, plays an important role in “waking up” these cells.
Neuronal stem cells are important for brain repair and regeneration. However, as we age, fewer of these cells may be activated, leading to the development of neurological diseases. The team found that SUMOylation affects the Hippo pathway, specifically the Wart protein, which normally limits stem cell reactivation. When modified by SUMO proteins, the inhibitory effect of warts is weakened, allowing brain stem cells to proliferate and regenerate.
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Source: Ferra
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