Researchers from Russia have developed a way to fix albumin, a blood protein, on the surface of magnetic nanoparticles. The scientists’ work was published in the journal Pharmaceutics.
Currently, many scientists are working on the creation of hybrid particles that could carry a payload in the form of drugs or aid in the diagnosis of diseases. This cannot be done without particle biocompatibility.
Researchers from the Institute of Biochemical Physics. NM Emanuel RAS developed a method in which albumin is oxidized on the surface of magnetic nanoparticles and forms a highly stable coating. The scientists tested their development on mice transplanted with cancer cells. The particles were imaged in tumors for more than 14 days, suggesting the possibility of their use for extended drug release.
In addition, the scientists evaluated the ability of particles with a stable albumin coating to accelerate the production of reactive oxygen species – this could be used as a tool for influencing tumors. No side effects were found when nanoparticles were used.
Source: Ferra
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