Researchers from Russia have developed a “universal container” for the delivery of a messenger RNA vaccine to human cells. The results of the study were published in the journal Pharmaceutics.

Currently, more and more vaccines are being created based on the genetic material of pathogens. To choose the right sequence, biochemists examine the proteins of pathogens and determine from which messenger ribonucleic acid (mRNA) they are synthesized. With the introduction of the mRNA vaccine, there is no contact with the disease-causing agent. The researchers note that such drugs are cheaper and faster to obtain.

However, there are challenges – such drugs require a “container” to deliver the mRNA to its target. One of the most effective systems for introducing substances into the body are liposomes – balls with a fatty shell filled with water. Researchers from SPbPU, MIREA and the Influenza Research Institute. AA Smorodintsev suggested his original compositions for the most effective delivery. Consequently, it is possible to insert mRNAs of various sizes and parameters into such liposomes.

The efficiency of protein-antigen production in living cells was experimentally tested by scientists on human cell cultures. The researchers stressed that the proportion of cells in which the protein is actually produced is comparable to commercially available foreign delivery systems.

Source: Ferra

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