birth control pills for men This is one of those scientific problems for which efforts are made, but fair ones. After all, there is already one for women. It doesn’t matter that many have to deal with the side effects of constant hormonal increases. It’s time to buy the perfect pill for men. One that prevents them from getting their partners pregnant, but with as few side effects as possible. Some clinical trials of hormonal pills have already been conducted; But, as is the case with women, Side effects there were quite a lot of them. In some cases, it must be admitted, they were terrifying. For this reason, steps have been taken, but none of these drugs have been marketed. Now, finally, the hormone-free male birth control pill has reached the phase clinical trials.
It was previously tested on mice and gave very good results. For this reason, the first phase of human clinical trials has begun and is expected to be completed. mid-2024. If all goes well, we will have to continue climbing and finally obtain the necessary permits to commercialize it.
All this indicates that the male birth control pill is still several years away from becoming a reality. Meanwhile, men can only use condoms or have a vasectomy. Women will still carry hormones.
Clinical trials that were canceled
This is the first clinical trial of male contraceptive pills. without hormones. Clinical trials of hormonal drugs have been conducted in the past. But the side effects were so intense that they were canceled.
Most of them were at skin level, especially if you have a lot of acne cases. However, there were also humor changessome of which became so intense that they ended in suicide attempts.
It was believed that something similar could happen in women. However, more recent research has disproved the existence of anything more than a chance correlation. In the case of the male contraceptive pill, it was not specified whether this was a coincidence. This was considered a serious enough side effect to stop the clinical trial.
Now there is a new drug called YCT-529is also starting to go down the path of clinical trials, but this time without hormones.
How do these male birth control pills work?
YCT-529 is a contraceptive pill for men. acts by inhibiting the alpha-retinoic acid receptor. Retinoic acid is a derivative of vitamin A, which is essential for sperm synthesis. But in order for it to perform its function, it must first become attached to its recipient. If the receptor is inhibited, as if we inserted a wire into a lock, retinoic acid will not be able to insert the key and sperm will not be synthesized.
In studies on mice, it was observed that pregnancy was prevented effectively 99%. In addition, there are practically no side effects, and the effect is fully expressed. reversible. Once you stop taking male birth control pills, sperm can be synthesized again without any problems. The cable comes out of the lock.
As is usually the case in the first phase of clinical trials of any drug, very few people will participate. More precisely, two cohorts of 8 volunteers each. With their help, efficiency will be analyzed, but above all safety and tolerability of YCT-529.
If all goes well, new phases of clinical trials will be advanced, enrolling more volunteers, and the dosage, effects and proper functioning of this male contraceptive pill will be described in more detail. Step by step. Time will tell if we have finally reached final preparation.
Source: Hiper Textual
