They find a tablet that delays the appearance of type 1 diabetes

Sometimes an ideal drug for the treatment of concrete disease takes a lot of time in pharmacies, but this aim at another type of treatmentThe field is exactly what happened to Type 1 diabetes. There is no treatment or any treatment that delays the symptoms. Patients have no other choice, except to resort to Insulin injections to normalize them The level of glucose in the blood. This is always annoying, especially when it comes to children, a group of population in which many cases of this disease are diagnosed. However, treatment that has been used for a long time Alopecia and arthritis also showed that it works like The drug is against diabetes To stop the progress of the disease and delay the onset of insulin injections as much as possible.

Said that the drug is called Baritinib And, although it was discovered for this purpose in 2023, he just took a new step towards the treatment of type 1 diabetes. Thank you Blind clinical trialsit was shown that its effectiveness can last a year, perhaps more, and that, in addition, Side effects are very scarce.

All of them are the advantages of this new drug against type 1 diabetes. You will have to conduct even more clinical trials before adding this new use once and for all, but everything goes in the essay, which has just been presented in The annual meeting of this year of the European Association for the Study of Diabetes (EASD)In Vienna.

How does type 1 diabetes happen?

Type 1 diabetes is an autoimmune disease in which the patient’s own immune system attacks Beta pancreaticis responsible for the secretion of insulin. Since the role of insulin is to regulate the level of glucose in the blood, the peaks of this very dangerous may occur. Therefore, there comes a time when these patients Insulin must be introduced So his metabolism works normally.

How does this drug work?

Many autoimmune diseases are treated with drugs responsible for blocking signals that lead to Hyperactivity of the immune system. That is, those signs that force the immune system of patients to attack their own structures, as if they were external threats.

One of these drugs is Baricitinib. In your case, he stops this path, inhibiting the type of immune proteins, known as Janus KinazyThe field showed that it is very effective in the treatment of states such as Autoimmune alopecia, rheumatoid arthritis or ulcerative colitis. In 2023, it was also demonstrated that it could be effective as a drug for diabetes of the 1st type. However, its consequences were not known over time. Now, thanks to the test baptized as Bandit (Baricitinib with new type 1 diabetes), it is known that its consequences lasts over time, so that They can significantly slow down the normal progress of the disease.

What consisted of this essay?

To conduct this study, participation 91 people from 10 to 30 years old Which was diagnosed with type 1 diabetes for the previous 100 days. It was important that the diagnosis was recent. If the attack on the pancreatic cells for a long time produced for a long time, it is already more difficult to act.

Half of the patients took Baricitinib tablets per day for 48 weeks. The rest did the same with a placebo tablets. They did not know which of the two options received.

At the beginning of the essay and for weeks 12, 24 and 48, Peptide levels C. participants. This Insulin secretion markerTherefore, it serves as an indicator of the condition of the pancreatic cells. If this is good, the patient may continue to synthesize insulin. A glucose levels and hba1c, which acts as an indicator of the long -term level of sugar.

What were the results?

After 48 weeks, Peptides C levels were 0.65 in the group of baritinib and 0.43 in placebo. This clearly indicates that those who received a drug for diabetes produced their own insulin with greater effectiveness. However, after Surge the treatmentPeptides C levels fell to 0.49 in the Baricitinib and 0.36 group in the placebo group after 72 weeks, and then by 0.37 and 0.26, respectively, after 96 weeks. This means that this was not a coincidence. This is a barinitinib that saved the pancreatic cells. When it was removed, the synthesis of insulin was difficult. In fact, after 72 and 96 weeks of treatment of patients already They needed to introduce almost the same amount of insulin as those who did not prove the drug.

What happened to glucose?

Logically, all this also led to greater control of short and long -term levels of glucose in the blood under the influence of the drug, but their deterioration over time After the cessation of treatment.

This indicates that, in addition to alopecia and other autoimmune diseases, baritsitinib can be an ideal option for Patients with type 1 diabetes in the early stages. In fact, these researchers believe that perhaps this may be a good option for treatment Even before the appearance of symptoms, In people with a great genetic predisposition to this disease. This is what they want to try in another clinical test.

In any case, everything will go faster than with a medicine discovered from scratch, since many patients received it with other goals and Your safety is more than provenThe field is possible, finally, this is a medicine that has been waiting for so many patients with type 1 diabetes.