A recent study explained why the pain be more intense during the night. For example, chronic pain or injury, why do they hurt more at night? The explanation is in circadian rhythms those are 24-hour cycles in which physiological functions repeat. The repetition of these functions is regulated by our biological clock, but also by light and temperature.
The Lyon Neuroscience Research Center has proven that the time of day and circadian cycle it has a major impact on the perception of pain. In fact, this was felt at its peak at 3 a.m. and then minimally painful at 3 p.m. Thereafter, the pain threshold increased from midday to early morning and then decreased from early morning to the following afternoon.
The study participants lay in low light for 34 hours. They did not sleep, but ate every two hours. So scientists have proven that sensitivity against the participants’ pain by using a hot device on their skin. Here the intensity of the pain has the peak between three and four in the morning before decreasing in the next twelve hours.
This is a precise variation in the reception of pain and may have to do with the molecular clock of every cell in our body. Useful information to administration from painkillers which are in fact given in the morning, while the greatest pain is at night. In addition, circadian rhythms also regulate hunger and sleep.
Source: Lega Nerd

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