According to a new study led by scientists at the Federal University of São Paulo (Unifesp), infection caused by SARS COV-2 responsible for changing its operation. RNA of the host cell and thus causing a larger viral infection🇧🇷 Article published in scientific journal Boundaries in Cellular and Infectious Microbiologyin August 2022.

To conduct the research, the scientists analyzed the epitranscriptome of monkey-derived cells (Vero) and human-derived cells (Calu-3) while sequencing the RNA. The epitranscriptome includes all the biochemical changes that occur in RNA such as methylation, a modification that occurs in cells by the action of enzymes that transfer part of one molecule to another.

According to Marcelo Briones, a professor at Unifesp School of Medicine and one of the authors of the article, methylation has two important functions in viruses: regulating protein expression and defending the virus against the effects of interferon, an antiviral substance produced. in the host organism.

“Our first major finding in this study was that SARS-CoV-2 infection increased m6a levels. [N6-metiladenosina]kind of methylation in host cells compared to uninfected cells,” Briones said in a statement.

Changes in SARS-CoV-2

Unifesp scientists analyzed m6a, the most common RNA nucleotide modification – responsible for different important processes such as intracellular localization and protein translation. In this way, they discovered that some strains of the virus can be more methylated than others and replicate the virus much more effectively within a host.

as well as opening more avenues for new treatments against Covid-19The study will also help scientists understand how different variants escape the infected person’s immune system. Now, the researchers’ next step is to analyze the relationship between the degree of methylation and the phenomenon of viral burst when the virus is released from each infected cell.

Source: Tec Mundo

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