A thematic project led by researchers from the Institute of Biomedical Sciences at the University of São Paulo (USP) since June 2019 has already received six national and international awards for proposing a known and simple solution to control high blood pressure: physical exercise🇧🇷
However, the recognition of the scientific community is not for the logical solution, but rather for how it happened. Scientists say that in hypertensive individuals or carriers of heart failure, aerobic training has succeeded in improving blood flow. by preventing damage to the so-called blood-brain barrier🇧🇷
The blood-brain barrier (BBB) is a structure that prevents the passage of substances from the blood to the central nervous system and prevents their entry into this region. – immunologically isolating itself from the rest of the organism – toxic substances, antibodies, plasma hormones and coagulation factors. In excess, some of these substances can lead to autonomic dysfunction and circulatory imbalance.
The blood-brain barrier and physical activity
The BBB consists of endothelial cells lining the cerebral capillaries formed by the endothelium and a thin basement membrane. This barrier has tight junctions with low permeability regulating the passage to the nervous tissue, both useful substances for neurons and drugs and toxic particles.
According to Lisete Compagno Michelini, coordinator of the Cardiovascular Physiology Laboratory at USP, “this transit of macromolecules through blood vesicles is highly limited” in normal individuals. However, there is an increase in these vesicles in autonomic regions in hypertensive patients and patients with heart failure. This makes the BBB more permeable.
“On the other hand, we observed that aerobic training greatly reduced the formation of these vesicles as well as normalizing the permeability of the blood-brain barrier,” explains Michelini in a statement. demonstrates the importance of physical education to improve neural control of circulation. This means fewer drugs and fewer side effects.
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Source: Tec Mundo
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