Researchers from Russia have proposed a new implant architecture that allows you to quickly restore damaged bone tissue. The scientists’ work has been published in the journal Stem Cell Research & Therapy.
Biomedical development is based on heterogeneous scaffold technology. These 3D lactic acid transporters are essentially scaffolds for tissue repair. The patient’s stem cells are placed in a 3D-printed model, which is then implanted into the damaged area.
The experts tested their development on mice with massive damage — four to five millimeters — to the skull over three months. Cell scaffolds were inserted into these defects – three-layer plates made of round cylinders of different diameters – and the formation of bone tissue was observed. It turned out that bone regeneration with new implants is twice as fast as with standard ones. Other processes are also more intense with their help: supply of oxygen, nutrients, mineralization.
One of the researchers, who is head of the molecular genetics research laboratory at the Clinical Institute, notes that many cells in the scaffold repeat the heterogeneous structure of bone – with large pores on the inside of the implant and smaller pores on the outside – allowing blood vessels to grow. UNN’s medicine. N.I. Lobachevsky Daria Kuznetsova. The rate of resorption corresponding to the rate of bone regeneration can be adjusted.
Source: Ferra
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