A study published in the journal Science found that inhibiting the enzyme indoleamine 2,3-dioxygenase 1 (IDO1) can improve memory and brain function in models that mimic Alzheimer’s disease. IDO1 inhibitors, currently in development to treat cancers such as melanoma and leukemia, could potentially be used to combat neurodegenerative diseases.
The researchers showed that blocking IDO1 improved glucose metabolism in astrocytes (brain cells critical for supporting neurons), thereby reversing cognitive decline.
The findings suggest that IDO1 inhibitors could not only slow but also reverse the progression of Alzheimer’s disease, offering new hope to patients who currently rely on treatments that only treat symptoms.
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Source: Ferra
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